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Chronic Iron Overload (IO)


Understanding Chronic IO
  • There are many conditions that require occasional or frequent transfusions, including:
    • Sickle cell disease
    • Thalassemia
    • Lower-risk myelodysplastic syndromes (MDS)
    • Other types of anemias
  • If you have had even as few as 10 red blood cell (RBC) transfusions over the course of your lifetime, you may be at risk for chronic iron overload (IO). Also, 1 RBC transfusion can add almost 100 times the amount of iron you normally receive from eating and drinking


Tracking your serum ferritin (SF) levels monthly will help determine if you have chronic IO

  • Consistently high SF levels (greater than 1000 mcg/L) may indicate that there is too much iron in your body
  • SF levels tell you how much iron is in your blood using a blood test

Before starting treatment with JADENU® (deferasirox) tablets, or JADENU® Sprinkle (deferasirox) granules, your doctor may order tests to check liver and kidney function, as well as eyesight and hearing.


It is important to know and keep track of blood transfusion levels. Download our JADENU Serum Ferritin Tracker in the Patient Support section.